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Figure 4


Fig. 4. Expression of lens-specific genes in Ndst1 mutants. (A-F) At the 26- to 28-somite stage, Pax6 and Six3 were detected in the lens placode (LP), but the level of their expression was reduced in severely affected Ndst1 mutants (arrowhead). (G-O) Molecular defects in Ndst1-mutant lens vesicles at the 35-somite stage. As the lens vesicles invaginated, expression of AP2, Prox1 and {alpha}A crystallin was downregulated in severely affected mutant lens vesicles (arrowheads in I,L,O). Notice that AP2{alpha} expression was still detectable in the overlying ectoderm and Pax6 expression was not perturbed. OV, optic vesicle; LP, lens placode; LV, lens vesicle; RE, retina.