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Figure 2


Fig. 2. Homeotic transformations and ectopic Hox gene expression in eedxBmi1 mutants. (A) The chart summarizes the penetrance of posterior homeotic transformations in P0 skeletons. The inset depicts the color-coding of the five transformations assessed. The columns represent the percentage of skeletons exhibiting the cervical (C), thoracic (T), lumbar (L) or sacral (S) transformations. Unilateral and bilateral transformations were combined. See the legend for Fig. 3 for a description of the transformations. The genotypes and the number (n) of skeletons analyzed per genotype are shown at the bottom of the figure. (B) The chart summarizes the penetrance of ectopic Hox gene expression in prevertebrae of E12.5 embryos. The inset depicts the color-coding of the four Hox genes tested (Hoxa5, b6, c8 and b4). The columns indicate the percentage of embryos exhibiting ectopic Hox gene expression. The genotypes and the number (n) of embryos analyzed per genotype and Hox probe are shown below the columns.