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Fig. 2. Phenotype of compound Cdx2+/-/Cdx4-/0 mutant embryos. (A) Gross morphology of a wild-type and Cdx2+/-/Cdx4-/0 compound mutant littermate at E10.5, showing developmental retardation of the compound mutant embryo. Thoracic edema (arrowhead in A) indicates a defect in embryonic circulation. (B,C) Close up of the tail bud of a E10.25 wild type (B) and Cdx2+/-/Cdx4-/0 mutant (C), showing the posterior truncation. TB, tail bud; HL, hindlimbs; FL, forelimbs. Scale bar: 500 µm.