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Fig. 1. Fz5/8 protein. (A) Schematic representation of Fz5/8. Blue, signal peptide; red, cysteine rich domain; green, transmembrane domain; black, KTXXXW motif. (B) Cladogram of representative members of the Frizzled family. Amino acid sequences of Frizzled proteins from sea urchin and other organisms were aligned using ClustalX and the tree was drawn with Tree View.