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Fig. 4. Perturbation of Fz5/8 function during embryogenesis. (A) Structure wild-type or dominant-negative forms of Fz5/8 encoded by cDNA constructs. S, signal peptide; CRD, cysteine rich domain; TM, transmembrane domain. (B) Phenotypes associated with the overexpression of FzE or FzTM1. B1-B3, gastrula stages; B4-B6, pluteus. (C) Rescue of FzTM1 phenotype. Control (left), injection of FzTM1 alone (middle), and co-injection of FzTM1 and Fz in a 1:2 ratio (right).