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Figure 1


Fig. 1. Different models explaining how NSCs in the pMN domain might generate differentiated cell types. (A) NRP/GRP model. (B) MNOP model. (C) Sequential model. Ast, astrocyte; MN, motoneuron; MNOP, motoneuron and oligodendrocyte common progenitor; N, neuron; NA, neuron and astrocyte common progenitor; OPC, oligodendroctye precursor; O, oligodendrocyte; pA, astrocyte precursor; pM, motoneuron precursor. Olig+ cells are orange; NSCs at different stages in the sequential model are coded in different colors to reflect restrictions in competence.