Fig. 6. Effect of uri-1 depletion on meiotic cells. (A) Loss of uri-1 sensitizes meiotic germ cell to apoptosis. Apoptotic germ cell corpse numbers in the heterozygous uri-1 mutant and uri-1(RNAi)P0 animals (n=40 each) reveal a gla phenotype, which is completely suppressed by mutations in the apoptotic pathway components ced-3(lf)and ced-9(gf) (^*P=3.0x10^-20, ^#P=2.3x10^-19). Error bars represent s.d. (B) Apoptotic germ cell corpse counts in wild-type and cep-1 germlines of uri-1(RNAi)P0 and control animals (n=40 each) reveal that the gla phenotype that is associated with loss of URI-1 is completely suppressed by loss of the DNA damage sensor p53 (C. elegans cep-1). Error bars represent s.d.