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Figure 2


Fig. 2. Rescue of early Fgfr1 functions by Fgfr1{Delta}Frs. (A) Viability (percent of expected) of homozygotes recovered from Fgfr1{Delta}Frs/+ and Fgfr1{Delta}ex4/+ intercrosses. (B-G) Sonic hedgehog (Shh, E9.5) and Meox1 (E10.5) in situ hybridization. Arrows indicate width of the Shh expression domain (more than two cell diameters in Fgfr1{Delta}ex4/{Delta}ex4 compared with one cell diameter in control embryos). (C) The paraxial mesoderm population is reduced and disorganized in Fgfr1{Delta}ex4/{Delta}ex4 embryos, so Meox1 staining is faint and diffuse. (Color development time required to visualize any positive signal was notably longer in this embryo than in F,G.)