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Figure 10


Fig. 10. FAK is required for somitogenesis and FN matrix deposition. (A) Immunoblot showing levels of FAK and FRNK in control (left lane) and FRNK-injected (right lane) embryos. (B) FRNK expression inhibits autophosphorylation at Y397; {alpha}-fodrin serves as a loading control. (C) Inhibition of FAK results in somite defects including misorientation of cells (arrow) and impaired somite boundary formation (arrowheads). FRNK-injected side is at the bottom and anterior is to the left. (D,E) Immunostaining of FN matrix in control (D) and FRNK-injected (E) BCRs show that FAK is required for FN matrix deposition. Scale bars: 100 µm.