Fig. 6. Shh aggregation by Dispatched can overcome diffusion limitations. The Gli1 protein interface position at t=83 hours is shown at various levels of (A) initial Dispatched intracellular concentration and (B) diffusivity of a Shh aggregate. Simulation initial conditions and parameters are the same as those listed in Fig. 2; however, Dispatched mechanism parameters and equations were added (see Fig. S4 in the supplementary material).