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Figure 3


Fig. 3. NEPH-B2 transgene-derived laminin ß2 accumulates specifically in the GBM. (A,B) Antibody specific for transgene-derived rat ß2 does not stain kidney glomeruli (g) from a control mouse (A) but stains GBM in kidney from NEPH-B2 transgenic mice (B). (C,D) NEPH-B2 transgene-derived ß2 is not deposited at skeletal muscle synapses (C) identified by double staining with {alpha}-bungarotoxin (D). Scale bar: 50 µm in A,B; 20 µm in C,D.