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Figure 8


Fig. 8. Analysis of laminin ß chain composition in glomeruli. (A,B) In Lamb2+/-; NEPH-B2 mice, the GBM contains rat laminin ß2 (A), and laminin ß1 is restricted to the mesangial matrix (B). (C,D) In Lamb2-/- mice, no ß2 is present in the GBM (C); instead, ß1 is present (arrows in D). (E,F) In Lamb2-/-; NEPH-B2 mice, rat ß2 is deposited into the GBM (E), and ß1 is restricted to the mesangial matrix (F) as in controls. Scale bar: 25 µm.