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Figure 2


Fig. 2. NF-{kappa}B activity during embryonic vibrissae and hair follicle development analysed in NF-{kappa}B-driven ß-Gal reporter mice. (A) Whole-mount X-Gal staining of E10-13 (Ig{kappa})3xcona-lacZ ({kappa}Gal) embryos. At E10-11, NF-{kappa}B activity is observed only in somites and endothelial cells of blood vessels. From E12 onwards, activity is seen in vibrissae follicles and the rim of the eyelids (see also insets E12 and E13). (B) Sagittal sections of X-Gal stained embryonic and newborn skin were performed to analyse the most important stages of murine pelage hair follicle development. At E13.5, arrows indicate endothelial cells of blood vessels. M, matrix; Co, pre-cortex; DC, dermal condensate; DP, dermal papilla. Broken line indicates the boundary between epidermis (Epi) and dermis (Der).