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Figure 6


Fig. 6. Csw/SHP-2-Spry feedback circuit shapes RTK signaling profile. (A) Ligand binding to RTK activates RAS/MAPK cascade, Spry negative-feedback loop (red), and Csw/SHP-2 tyrosine phosphatase (green). Csw/SHP-2 dephosphorylates Spry, inactivating it. This creates a double-negative regulatory circuit in which Csw/SHP-2 increases RTK output by inactivating a feedback inhibitor. (B) Conceptualized plots of RTK kinetics when no feedback (black), Spry feedback (red) or the complete Csw/SHP-2–Spry circuit (green) is operative.