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Figure 1


Fig. 1. FOI is a member of the ZIP family of zinc transporters. (A) Diagram of the FOI protein with conserved domains highlighted. Mutations introduced into HA-FOI are specified. (B) Sequence alignment of highly conserved domains (as indicated) of representative ZIP proteins from different subgroups. Adapted, with permission, from Mathews et al. (Mathews et al., 2005). Alternative nomenclature for these same proteins is included in the lower alignment. Residues tested for function in gonad morphogenesis are indicated (brackets link mutations introduced together). (C) Deconvolution images of Drosophila S2 cells transfected with the indicated UAS-foi constructs and immunolabeled with {alpha}-HA (red) before permeabilization. DAPI (blue) labels the nuclei. Scale bar: 10 µm.