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Figure 8


Fig. 8. Models of zinc regulation of DE-cadherin. Human and zebrafish LIV1 proteins may function as zinc transporters to activate SNAIL, a repressor of E-cadherin transcription. Drosophila FOI may activate Escargot (an activator of DE-cadherin) in the trachea, and is required for both DE-cadherin transcription and RNA stability in the gonad.