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Figure 1


Fig. 1. Hand functions as a potent transcription activator. (A) Schematic drawing of the Hand mutant constructs for structure/function studies. (B) Activation of the L8E6 promoter by Hand and deletion mutants. (C) Mapping the transcription activation domain of Hand with Gal4-Hand fusions. (D) Hand-EnR blocks the transcriptional activity of wild-type Hand on the L8E6 promoter in a dosage-dependent fashion. All experiments were carried out in Drosophila S2 cells.