Fig. 6. Delta1 conditional knockout mice have vestibular defects. Coronal cryosections of vestibular regions of the inner ear of mutants and littermate controls stained with Jag1 antibody and fluorescent phalloidin. (A,B) Saccule. The saccular macula is much smaller (and sometimes missing) in the Delta1 conditional knockout (B), when compared with the Foxg1-Cre littermate control (A). (C,D) Utricle and horizontal crista. The utricular macula is also drastically reduced in the mutant (D) compared with the control (C), though the crista is less affected.