(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. Model for EPP cell cyst formation. Mesenchymal-to-epithelial transition specifies EPP cells expressing WT1 and {alpha}4 integrin. Cell-cell contacts and integrin-mediated contacts to the extracellular matrix provide spatial cues for epithelial cell polarity. PAR3 interprets the spatial cell polarity cues to localize PAR6ß and aPKC, leading to the establishment of apical cortical domains of EPP cells. Completely polarized EPP cells can then form EPP cell cysts. By contrast, Par3{Delta}E3/{Delta}E3 EPP cells fail to localize PAR6ß and aPKC, and cannot establish the apical domains.