Fig. 3. Abnormal morphology of the olfactory bulb in Fez-deficient mice. (A) The olfactory bulbs were smaller and farther apart in Fez-deficient embryos (right) than in wild-type embryos (WT, left), at P0. (B-E) Nissl staining of sagittal sections of the head region of E14.5 (B,C) or E18.5 (D,E) wild-type (B,D) and Fez-deficient (C,E) embryos; anterior to the right. Scale bars: 0.5 mm. (F-I) Nissl staining of coronal sections of olfactory bulbs from E14.5 (F,G) or E18.5 (H,I) wild-type (F,H) and Fez-deficient (G,I) mice; medial to the right. The olfactory bulb was smaller in Fez-deficient embryos than in wild-type embryos at E18.5 and P0. An irregular formation of the mitral cell layer (arrows, D,H,I) was detected in Fez-deficient embryos at E18.5.