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Figure 7


Fig. 7. FGF16, but not FGF2 or FGF7, promotes survival of 11.5 dpc XY gonocytes. Gonocytes of 11.5 dpc Oct4:GFP embryos were purified (>95%) and cultured in DMEM alone or in DMEM + 25 ng/ml FGF2 (A), + 25 ng/ml FGF7 (B), + 25 ng/ml FGF16 (C) or + 40 ng/ml FGF16 (D). FGF2 and FGF7 show no effect on gonocyte survival (A,B). However, XY gonocytes and gonocytes cultured in DMEM + 25 ng/ml FGF16 (C) or + 40 ng/ml FGF16 (D) exhibit significantly improved survival after 36 hours in culture (n=10 for each time point; P<0.01).