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Figure 4


Fig. 4. Tooth and hair placodes do not form in p63 null mutants. (A,C) The placodes of incisors and molars are visualised by Pitx2 and Shh expression at E12 in the wild-type mandible. (B,D) In mutant mandibles, Pitx2 and Shh remained continuous in the dental lamina, indicating the absence of placodes. (E,G) ß-catenin and Edar are early markers of hair placodes in wild-type skin at E14. (F,H) In p63 null skin, ß-catenin and Edar expression was absent. i, incisor; m, molar placode.