Fig. 3. Two morphological abnormalities observed in E7 NT embryos. (A,C) Control embryos at early-streak (A) and mid-streak (C) stages. (B) Two examples of NT embryos with abnormal rounded shape at pre-streak (left) and early-streak stage (right). (D) The normal proportion of the embryonic and extra-embryonic regions is perturbed in some NT conceptuses (Exe phenotype). (E) Mean ratios of the epiblast (=number of cells in epiblast/total cell number, in %) in controls (black), in NT displaying the Exe phenotype (white), and in other NT embryos (grey). Scale bars: 100 µm. ^*P<0.01.