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Figure 7


Fig. 7. The level of Shh signaling correlates with size and number of lobules. Histological analysis of adult cerebella shows Shh-P1 transgenics (B) have a larger cerebellum than normal (A), with longer lobules and bumps in specific locations (e.g. arrow). Shh-P1;Ptch1+/- mutants (C) also have longer lobules and an extra sublobule forms (arrow) which corresponds to a sublobule (arrow) present in the adult rat (D). Scale bar: 500 µm.