Fig. 2. Expression patterns of Edar and BMP inhibitors in wild-type molar teeth. In situ hybridization with probes specific to Edar (A,B), noggin (C,D), gremlin (E,F), Dan (G,H) and bambi (I,J) at the placode stage (A,C,E,G,I) and at the cap stage (B,D,F,H,J) of tooth development. Edar is expressed in the dental placode (arrowhead) at E12, and in the enamel knot (arrow) at E14. Noggin, gremlin and Dan were detected only in the mesenchyme, whereas bambi was also expressed in the epithelium overlapping the enamel knot at E14.