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Figure 6


Fig. 6. Downregulation of wnt expression in early-stage fezl-overexpressing embryos. (A-R) Bud-stage embryos. The expressions of emx1 (B), tlc (D), wnt8b (F,P), fgf8 (H) and six3b (R) were unaffected in fezl-overexpressing embryos at the bud stage, whereas the expression of wnt1 (J,N) and pax2a (L,N,P) was defective in bud-stage fezl-overexpressing embryos. Arrowheads in A-P indicate the MHB; arrows in K,L indicate the otic placode. (S-X) 10-somite-stage (10s) embryos showing altered expressions of six3b (T), wnt8b (V) and fgf8 (X). All are dorsal views of the embryonic brain anlages. Stages and marker identities are specified in each panel. op, otic placode; e, eye region.