Fig. 2. Loss of Foxp2 leads to postnatal lung alveolarization defects.
(A-F) Hematoxylin and Eosin staining of wild-type and
Foxp2-/- mutant mice revealing dilated airspaces in the
Foxp2 mutant lungs at E18.5, P8 and P20. (G) Mean linear
intercept (MLI) calculation of wild-type and Foxp2 mutant lungs at
the indicated times showing airspace enlargement in Foxp2 mutant
mice. (H,I) TEM of wild-type (H) and Foxp2 mutant lungs
(I) does not reveal a significant change in alveolar epithelial morphology at
P8. Scale bars: 500 µm in A-F.