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Figure 7


Fig. 7. Hand2 is not required for precursor cells to begin neuronal differentiation. (A-F) ß3-tubulin+, GAP-43+ and PGP9.5+ neuronal precursors are present, but at a lower density, in the Wnt-1-CreH2{Delta} gut than in wild type. (A) ß3-tubulin immunoreactivity; (B) ß3-tubulin cell density; (C) GAP-43 immunoreactivity; (D) GAP-43-cell density; (E) PGP9.5 immunoreactivity; (F) PGP9.5 cell density. (G) GAP-43 (green) and PGP9.5 (red) immunoreactivities are fully coincident in wild-type (WT) mice (top) but, in Wnt-1-CreH2{Delta} animals, many PGP9.5+ cells lack GAP-43 (bottom). (H) Neural precursors lose Sox10 (green) immunoreactivity while retaining that of Phox2b (red) in both wild-type fetuses (top) and Wnt-1-CreH2{Delta} mice (bottom). Scale bars: 50 µm.