Fig. 10. DiI labelling of commissural neurons in P10 CxCdk5KO and Cdk5^-/- mice. DiI crystals were placed in the cerebral cortex of fixed brains of (A) P10 CxCdk5KO and (B) E18.5 Cdk5^-/- mice and littermate controls. Vibratome sections (100 µm) were imaged using a fluorescent (A,B) or confocal (inset in B) microscope. (A) Abnormal dendrite development of commissural neurons in CxCdk5KO mice. Scale bar: 25 µm. (B) In Cdk5^+/+ mice, cortical pyramidal neurons extended their apical dendrites toward the pia. By contrast, Cdk5^-/- neurons extended their dendrites in multiple directions. Inset, confocal image of abnormal dendrite structures of Cdk5^-/- commissural neurons.