Fig. 5. Cited2 and Wt1 are in the same genetic pathway. Genetic interaction between Cited2 and Wt1 was analysed by interbreeding Cited2^+/- and Wt1^+/- mice. Urogenital regions from embryos of the four resulting genotypes were analysed by WISH for Sf-1 at E11.5 (left panel). Adrenal surface was measured as the non-gonadal area staining positive for Sf-1 (arrowhead) and is expressed as a percentage of wild-type surface (right panel). Results are the mean of three independent experiments; ^*, P<0.05 in Student's t-test.