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Figure 2


Fig. 2. Lack of a Pre-AER/AER leads to loss of Fgf10 maintenance in mutant mouse hindimbs. Transverse sections through (A,B) E9.5 (31ss) and (C,D) E10.5 hindlimb buds. Note the lack of pre-AER (B) and AER (D) in mutants as compared with normal controls (A,C). (E-J) Dorsal views of whole-mount hindlimb bud region stained with the probe at the somite stage indicated. Mutant Fgf8 expression is not induced (F). Mutant Fgf10 expression is induced (H) but is not maintained (J).