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Figure 2


Fig. 2. Removal of ß-catenin in renal vesicle progenitor cells in mice results in reduced tubulogenesis and branching. (A,B) Whole-mount in situ hybridization of HoxB7 (a marker for ureter) and (C-J) mesenchymal induction markers (Fgf8, Wnt4, Pax8 and Lhx1) on E12.5 embryonic kidneys from control (A,C,E,G,I) and LOF mutants of ß-catenin (B,D,F,H,J). Black arrowheads point to expression of mesenchymal induction markers in ß-catenin LOF mutants.