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Figure 3


Fig. 3. Kidneys from GOF mutants of ß-catenin show ectopic expression of early tubule markers and reduced branching in mice. (A,B) Histology of kidneys from wild type and GOF mutants of ß-catenin at E13.5. Active nephrogenesis occurs in the cortex of wild-type kidneys (A), but neither S-shaped body nor nephron is formed in GOF mutants of ß-catenin (B). (C,D) Whole-mount in situ hybridization of HoxB7 and (E-L) the mesenchymal induction markers (Fgf8, Wnt4, Pax8 and Lhx1) on E12.5 embryonic kidneys from wild type (C,E,G,I,K) and GOF mutants of ß-catenin (D,F,H,J,L). White arrowheads indicate ectopic expression of mesenchymal induction markers dorsal to the ureteric epithelium. CD, collecting duct; NZ, nephrogenic zone; PA, pre-tubular aggregate; SB, S-shaped body.