Fig. 7. Cell adhesion is important for early cell division cycles. (A) Genes that belong to the `cell junction' category in all of the eight groups of ERK-dependent genes were searched for by using GenMAPP/MAPPFinder software, and five genes were identified (red and purple). In the diagram, genes were color coded by the expression patterns that we assigned to each group. The figure is based on the Kyoto Encyclopedia of Genes and Genomes pathway database (http://www.genome.ad.jp/kegg/), with slight modification. (B) ECCD-1 treatment potentiates the sensitivity of embryos to U0126 treatment. Eight-cell-stage embryos were cultured for 24 hours in the presence of either 20 µM U0126 or ECCD-1 or both, and were then observed. The concentration of ECCD-1 used in the experiment was 1:500.