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Figure 3


Fig. 3. Normal development of ventral midbrain progenitors and Nurr1+ TH+ mDA neurons in Shhcko embryos at E12.5. (A-H) Coronal sections of mouse embryos. (A,E) Shh expression is missing in Shhcko embyos (E), whereas it is expressed in basal midbrain progenitors in control embryos (A). (B-D,F-H) Similar expression of Foxa1/2 and Nurr1 and TH in the ventral midbrain of Shhcko (F-H) and in control embryos (B-D). Scale bars: 75 µm.