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Figure 4


Fig. 4. Reduced expression of Ngn2 in mDA progenitors and incomplete specification of immature neurons in Foxa1-/-;Foxa2cko double-mutant embryos at E12.5. (A-F) Coronal sections of mouse embryos. (A,B) Ngn2 expression is reduced in mDA cells in mutant compared with wild-type embryos. (C-F) Lmx1a, Tuj1+ immature neurons are generated (C,D) that do not express Nurr1 and TH (E,F) in mutant as compared with control embryos. Scale bars: 75 µm.