Fig. 11. Genetic interaction between drl and Wnt5 during MB development in Drosophila. Different genotypes were assessed for the production of a drl-like phenotype. MB morphology was assessed using the anti-FASII antibody. These results indicate that reduced expression of lio⁺/drl⁺ associated with overexpression of Wnt5⁺ gradually leads to a drl-like phenotype. lio/+, lio² GAL4-c739/+. 1 UAS, GAL4-c739/+; UAS-Wnt5⁺/+. 2 UAS, GAL4-c739/UAS-Wnt5⁺; UAS-Wnt5⁺/+. lio/1 UAS, lio² GAL4-c739/+; UAS-Wnt5⁺/+. lio/2 UAS, lio² GAL4-c739/UAS-Wnt5⁺; UAS-Wnt5⁺/+. lio/drl, lio² GAL4-c739/drl^R343. n, the number of brains analyzed. +, wild-type; +/-, moderate midline crossing; -, complete midline crossing.