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Figure 1


Fig. 1. Lmx1a is selectively expressed in mesDA neurons and their proliferative progenitors. (A) Expression of Lmx1a in the mouse mesencephalon at E12.5. (B-F) Lmx1a is selectively expressed in the mesDA neurons. Lmx1a is co-expressed with Th (B), Lmx1b (C), Nurr1 (D) and Pitx3 (E) but not with Nkx6.1 (F) in the mouse ventral mesencephalon at E12.5. Only Lmx1a is expressed in the VZ region of the mesDA domain. (G-J) Lmx1a is expressed in the proliferative progenitors. Lmx1a was co-expressed with MPM2 (I) and Ngn2 (J), and Lmx1a+ VZ cells incorporate acutely injected BrdU (H) at E11.5.