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Figure 3


Fig. 3. Mis-specification of mesDA neurons in dreher embryos. Lim1/2 is expressed in RN neurons and is not co-expressed with mesDA markers in wild-type embryos (A,C,E). By contrast, Lim1/2 is ectopically expressed in Lmx1b+ (B,B'), Lmx1a+ (D) and Nurr1+ (F) neurons (arrowheads). Note that these Lim1/2+ mesDA precursors do not express Th. (G) Model of Lmx1a function in postmitotic mesDA specification.