Fig. 7. mesDA neurons originate from FP cells. (A) Mouse early mesencephalic FP cells express Corin and Lmx1a but not proneural genes. (B) Mesencephalic FP cells sorted from E9.75 mouse embryos generate Nurr1⁺ mesDA neuron precursors in vitro. Note that Corin⁺ cells at the sorting period do not express proneural genes (A) and acquire neurogenic activity during culturing, suggesting that mesencephalic FP cells are intrinsically fated to acquire neural progenitor characteristics.