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Figure 5


Fig. 4. Roles for lipoprotein association in morphogen signaling. (A) Heteromeric receptor complex formation between Frizzled and LRPs (e.g. LRP1, Arrow/LRP5/6) via simultaneous binding of Wnt ligands and apoproteins in lipoprotein particle may affect canonical Wnt signaling pathways. (B) Binding of Hh-modified lipoproteins to Patched and to LRPs may control Hh signaling directly or via cellular uptake of sterols with regulatory function. Extrac., extracellular; Intrac., intracellular; PM, plasma membrane. TCF, T cell factor.