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Figure 4


Fig. 4. Phenotype of Mlc2a-/- mouse embryos. Heterozygous (A,C,E) and knockout (B,D,F) littermates at the 7-somite (A,B), 10-somite (C,D) and 23-somite (9.5 dpc) (E,F) stage. The capillary plexus is demarcated by GFP-expressing erythroblasts. At the 7-somite stage, blood islands have clearly formed in both wild-type (A) and Mlc2a-null (B) embryos and erythroblasts begin to circulate in both wild-type (C) and Mlc2a mutant (D) embryos. However, the plexus retains an immature phenotype and fails to remodel by embryonic day 9.5 in the mutant embryos (F), as compared with wild type (E).