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Figure 7


Fig. 7. Inhibition of FGF signalling does not block neural specification in Bmpr1a-/- mouse embryos. (A,B) No Hesx1 expression is observed in 6.5 dpc control embryos treated with either DMSO or 80 µM SU5402 and cultured for 24 hours. (C,D) Hesx1 is expressed in 6.5 dpc Bmpr1a-/fx; Sox2Cre+/- embryos after 24 hours culture in DMSO or SU5402. (E-H) Hesx1 expression is observed in 5.5 dpc control and Bmpr1a-/fx; Sox2Cre+/- embryos after 48 hours culture with SU5402, but not when cultured with DMSO. (I,J) 5.5 dpc Bmpr1a-/- embryos show similar levels of Hesx1 expression after 48 hours culture in DMSO or SU5402.