Fig. 2. Wnt signaling in morphogenesis and cell polarity. (A,B) A requirement for Ror2 in non-canonical Wnt signaling. Elongation and constriction of Keller explants (dorsal tissue from Xenopus gastrulae) used as a model of non-canonical Wnt5a signaling (see text). (A) Uninjected explant. (B) Ror2 morpholino-injected explant shows lack of constriction (arrows) during convergent extension movements. Image courtesy of Alexandra Schambony. (C) Asymmetric WRM-1-GFP localization during telophase in the V5.p cell of the C. elegans larva. Note cortical localization of WRM-1 in the newly forming cell on the left (arrow) and more-pronounced nuclear localization in its sibling cell on the right. Image courtesy of Kota Mizumoto. (D) Asymmetric ß-catenin localization in a 16-cell Platynereis dumerilii embryo. Animal pole view; -tubulin (green), and histone (blue). Sister cells are connected by white bars. Notice that ß-catenin (red) is present at high levels in the nuclei of vegetal-pole sister cells (arrowheads, magenta color), but at low levels in the nuclei of animal-pole sisters. Image courtesy of Stephan Schneider. See text for references. Scale bars: 150 µm in A for A,B; 2 µm in C.