Fig. 4. Gene structure of nab-1 and the domain structures of its predicted isoforms. (A) Predicted multiple isoforms encoded by the nab-1 gene. The expected molecular weight of each isoform is listed. Grey boxes; exons. Lines; introns. hpIs66 transgenic animals carry an integrated array of a construct where GFP sequence was inserted at the 3' end of the nab-1 gene just before the stop codon. The genetic lesion of the two nab-1-deletion mutants, gk164 and ok943, are shown. (B) The predicted isoforms of NAB-1 contain multiple protein motifs, except isoform c. The domain structures of the predicted isoforms of NAB-1 are shown schematically. The shortest isoform, C43E11.6c, does not contain any known protein motif.