Fig. 9. Invasive trophoblast cell distribution within day 11.5 uteroplacental compartments of wild-type and Dprp-null mice exposed to normoxia or hypobaric hypoxia. (A-C) Wild-type (+/+) and (D-F) Dprp-null (-/-) mice were exposed to normoxia (A,D) or hypobaric hypoxia (B,C,E,F). Trophoblast cells were identified by cytokeratin immunostaining. C and F are high magnification images of the areas delineated by the boxes in B and E, respectively. Note the decreased endovascular trophoblast invasion (arrowheads in C,F) in the Dprp-null mice exposed to hypoxia. The mesometrial region of the uterus is located at the top of each image. Scale bars: 1 mm for A,B,D,E