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Figure 4


Fig. 4. The immature and hypertrophic muscle phenotypes observed in {Delta}IG-DMR/+ embryos. Muscle morphology of normal (A,C,E) and {Delta}IG-DMR/+ (B,D,F) embryos at E19, stained with the myofibre-specific antibody MY-32. (A,B) Cross-sections of the forelimb. (C,D) High power views of the extensor carpi radialis longus. (E,F) High power views of the extensor pollicis longus muscle. (G,H) Morphometric analyses show that there are statistically significant differences, both in the proportion of myofibres with centrally-located nuclei (G; P<0.0001; Mann-Whitney U test), and in the mean myofibre cross-sectional area (H; P<0.0001, unpaired t-test). epl, extensor pollucis longus; ecrl, extensor carpi radialis longus; r, radius; u, ulna.