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Figure 6


Fig. 6. Methylation studies of the Dlk1-Gtl2 imprinted domain in placenta. (A) The IG-DMR region is fully methylated on the paternal chromosome and unmethylated in the maternal chromosome in placenta. The Dlk1-DMR (B) and Gtl2-DMR (C) are partially methylated on both parental alleles in the placentas, with methylation level being slightly higher on the paternal allele. (D) A placenta-specific differentially methylated region, Dlk1-DMR0, is identified ~7.4 kb upstream of the Dlk1 transcriptional start site. (E) Summary of the methylation status of the Dlk1-Gtl2 domain in embryos, sperm and placentas. White and black circles represent unmethylated and fully methylated regions, respectively. One, two and three quarters-filled circles represent alleles methylated by approximately 25%, 50% and 75%, respectively. M, maternal allele; P, paternal allele