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Figure 2


Fig. 2. Cardiovascular defects in Ltbp1L-/- mice. Gross dissections of newborn wild-type (A) and Ltbp1L-/- (B-E) mice with left or both atria removed to facilitate visualization of the great vessels. The ductus arteriosus is labeled with an asterisk in A-C. The great vessels are labeled as follows: Ao, aorta; PA, pulmonary artery; dAo, dorsal aorta; PTA, persistent truncus arteriosus. PTA with type B (B,E) and type C (C) IAA in Ltbp1L nulls. (D) PTA and a dextraposed aortic arch. (E) Ectopic position of a coronary artery (arrowhead). (F-I) Hematoxylin and Eosin-stained frontal sections of newborn hearts: (F,H) control; (G,I) mutant heart. PTA (G) is labeled with an asterisk. The membranous ventricular septum (G, arrow) and the atrial septum (I, arrowhead) are absent in the mutants.