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Figure 3


Fig. 3. Ltbp1L expression in the septating heart. Whole-mount (A) and lateral sections (B,C) of an E9.5 Ltbp1L heterozygous heart, stained with X-gal. Myocardial cells underlying outflow tract (OFT; B) and atrio-ventricular (AV; C) endocardial cushions express Ltbp1L (black arrows). Red arrows in A and B mark the thyroid primordium. (D-F) Lateral sections of E10.5 (D) and E11.5 (E,F) heterozygous hearts, stained with X-gal and Eosin. Myocardium (My) underlying OFT and AV cushions, mesenchymal cells (M) within the cushions and some E11.5 endocardial cells (E) express Ltbp1L. (F) Endoderm of pharyngeal pouches expresses Ltbp1L (arrows). The third, fourth and sixth pharyngeal arch arteries (PAAs) are labeled as 3, 4 and 6, respectively. (G-I) Transverse sections of an E12.5 heterozygous heart at the level of the ductus arteriosus (G), the fourth PAA (H) and the third PAA (I) stained with X-gal and Eosin. Arrows indicate Ltbp1L-expressing smooth muscle cells (SMCs) surrounding dorsal aortae and PAAs.